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Impact on Body Image and Self-Esteem: While weight loss can be a desired outcome for some, it can also trigger or exacerbate body image issues and anxiety for others

That is, compared to placebo (non-use) or active comparators (i.e., metformin, TZD, and insulin), use of SGLT2is significantly decreased visceral adipose tissue volume and liver enzymes (i.e., alanine aminotransferase [ALT], aspartate aminotransferase [AST])

Springer International Publishing, Cham, [cited 2025 Jan 29]

This is a natural biological response as the body attempts to defend its set point. Because tirzepatide interacts with an additional hormone receptor (GIP), it can sometimes provide the necessary metabolic nudge to overcome a plateau that occurred on semaglutide

Idilman R, Mizrak D, Corapcioglu D, Bektas M, Doganay B, Sayki M, et al

doi: 10.24869/psyd.2020.168