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As scientists have tinkered with GLP-1s, transforming a short-lived peptide into long-lasting injections, the molecules have grown large enough that they shouldnt be able to cross the blood-brain barrier

Clinical trials are needed to assess the safety and efficacy of these approaches in humans and to determine their potential to halt or reverse the DKD progression

Patients inject subcutaneously into the abdomen (at least two inches from the navel), front of thigh, or back of upper arm

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Astrogliosis, a common pathological phenotype in neurodegenerative disorders, is characterized by alterations in gene expressionsuch as the upregulation of GFAPand distinct morphological changes 4

The Ultraviolet-visible spectroscopy (UV-vis) spectra of all samples are shown in Supplementary Fig