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When semaglutide is discontinued, gastric acid production, gastric emptying speed, and appetite all return toward baseline over several weeks

The antioxidant response genes activated by NRF2 include genes responsible for (a) regulating GSH synthesis and metabolism, (b) antioxidant proteins like GPX, (c) drug-metabolizing enzymes and xenobiotic transporters, and (d) additional stress response proteins (Jaramillo and Zhang, 2013)

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