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Liraglutide and obesity in elderly: efficacy in fat loss and safety in order to prevent sarcopenia

Injection site affects absorption rate and peak concentration but does not fundamentally change how the medication works

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For example, GLP-1 enhances L-type Ca 2+ currents through activation of the cAMP-dependent PKA pathway in canine cardiomyocytes [71], whereas when rat hippocampal neurons are pre-incubated with GLP-1 for 24 h, Ca 2+ currents are significantly decreased [58]