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doi: 10.1038/srep37664 (2016)
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The FDA raised concerns about limited human trials, inconsistent chemical information, possible immune reactions and difficulty confirming the purity of finished products
In homozygous human FcRn Tg32 mice, groups of female and male mice (816 weeks, 21.530.0 g, 5 mice/23 cages/group) were given either IV or SC injection, into the scruff of the neck, of 4 mg/kg of GLP-1 albumin fusions, diluted in DPBS (pH 7.4) (Sigma-Aldrich), respectively
Releases copper to apo-enzymes and copper-dependent transcription factors a carrier-peptide role in controlled-stoichiometry delivery
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