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Researchers are in the early stages of studying the use of this class of drugs for addictive behaviors in humans, and experts have said unresolved questions about a potential addiction indication for semaglutide should elicit attention -- and caution -- from prescribers

Safety, Provider Guidance, and Genetic Context in Dose Selection GLP-1 receptor agonists carry established contraindications: personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia type 2, severe pancreatitis, or uncontrolled diabetic retinopathy

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The SUSTAIN and SELECT trials documented heart attack, stroke, and cardiovascular death rates that were either equal to or lower in semaglutide groups compared to placebo