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In cases of type 2 diabetes mellitus this incretin effect of GIP and GLP-1 are diminished, however the glucagonostatic effects of GLP-1 are preserved to the extent that stimulating the GLP-1 receptors significantly reduces plasma glucose and improves glycaemic control

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doi: 10.1111/j.1365-313X.1994.00397

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Decades of research have consistently shown GHK-Cu to be non-toxic and well-tolerated, which is a significant advantage when considering long-term application in research settings

A measurable increase in GLP-1 levels doesnt automatically mean weight loss