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We found that tamoxifen at concentrations, which accumulate in tumors during therapy, increases oxidative stress in ER-positive and ER-negative breast cancer cells, resulting in cell death

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Xu G, Ma Y, Jin J, Wang X

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Furthermore, exercise increases the protein abundance of factors that regulate lipid metabolism, such as hormone-sensitive lipase (HSL) and fatty acid translocase (FAT/CD36), and elevates mitochondrial markers like COX-IV, indicative of increased mitochondrial density and oxidative capacity

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