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A study of 5 patients showed an improvement in liver histology after 24 weeks of therapy with canagliflozin (205)

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[59] [60] During the 1970s greater police presence reduced crime and the city became home to those seeking to avoid business regulation and taxes

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The standard titration schedule begins with 0.25mg weekly for four weeks (a starter dose not intended for glycaemic control), increasing to 0.5mg, then potentially to 1mg after at least four weeks