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On the cellular level, a complex interplay of hormonal changes, alterations in enzymatic activity that modify extracellular membrane stiffness, and changes in biochemical and biomechanical signalling pathways disrupt collagen cross-linking within the stroma, contributing to structural integrity loss and distortion of normal corneal anatomy

Different molecular cascades are crucial for normal cell growth and cell-to-cell communication [2] so that changes in such signaling pathways can trigger tumor heterogeneity and aggressiveness [3]

El International Citicoline Trial on acUte Stroke (ICTUS) es un estudio multicntrico y doble ciego que evalu el efecto de suplementar a 2,298 pacientes con accidente cerebrovascular isqumico agudo con citicolina (2,000 mg/da) o un placebo durante seis semanas sobre varios resultados funcionales y neurolgicos y en la tasa de mortalidad (94)

Journal of Strenght and Conditioning Research 2003;17(3):455-462

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Vitamin B12 is not typically found in plants, so vegans and vegetarians may need to look for fortified breakfast cereals that include B12 or opt for a regular supplement (NIH, 2020)