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Dietary changes are high yield, with about 50% of patients finding relief from gastrointestinal symptoms after adjusting intake, which highlights sugar alcohols and fermentable carbohydrates as frequent triggers

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

However, early studies in patients with type 2 diabetes suggested impaired GIP responsiveness, leading many researchers to conclude that targeting GIP would be therapeutically futile [5]

most are heavily engineered analogs designed to artificially alter receptor binding, stability, and half-life

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