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Effect sizes differences were medium to large

Bottom Line Newer prescription weight loss drugs like Wegovy, Foundayo or Zepbound can produce dramatic weight loss results of 10 to 20% or more, but come with an initial risk of stomach-related side effects, like nausea, vomiting, diarrhea, constipation or stomach-area pain

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If you experience any severe symptoms outside of minor swelling or bruising at the injection site, including significant pain at the injection site that has not gone away by the next day, call your doctor immediately.

Four Common Short-Term Side Effects Most short-term side effects appear during dose escalation or the first weeks of treatment

Some people seek tirzepatide alternatives specifically because they want to move away from pharmaceutical approaches