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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

3.1 Tirzepatide effects: glucose lowering effects of tirzepatide Tirzepatide, a once-weekly subcutaneous injection, was FDA approved in May 2022 as an adjunct treatment with diet and exercise to improve glycemic control in adults with Type 2 diabetes [43]

Effect of glucagon-like peptide 1 receptor agonists on albuminuria in adult patients with type 2 diabetes mellitus: a systematic review and meta-analysis

If you start at a very high BMI, do not panic if the first 12 weeks produce modest results

Renal Extraction and Acute Effects of Glucagon-Like Peptide-1 on Central and Renal Hemodynamics in Healthy Men

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