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5.4 Clinical evidence: melatonin in ART cycles and PCOS-related infertility Clinical data on melatonin as an adjunct in assisted reproduction (and specifically in PCOS) converge on a plausible benefit for intermediate outcomes, with more cautious signals for hard endpoints

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Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability

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The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001