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[69] demonstrated that the knockdown of FoxO3a enhanced cellular senescence in human dermal fibroblasts indicating that FoxO3a might maintain cellular homeostasis, probably by enhancing autophagy

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These remain active research areas

The main strength of this article is the design and novelty of the RCT, given that this research was the first human study to investigate the effects of NAC administration on senescence and factors associated with metabolic disorders in obese subjects

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