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In addition, the latest guidelines classify microglial states into five major phenotypes: homeostatic, DAM-like, HLA/MHC class II, CRM or inflammatory, and interferon (IRM or IFN) clusters [105]

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The involvement of transition metal ions on iron-dependent lipid peroxidation

however, as long-term risks are unknown, it is limited to use in patients unresponsive to PEG