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Figure 6 Having demonstrated that metformin treatment significantly inhibits oxidative phosphorylation in both in vitro and ex vivo models of rectal cancer, the effect of metformin on histologically-confirmed normal rectal tissue biopsies ( n =12, median age of 41.5 y) taken from non-cancer patients was assessed in real-time using the Seahorse XFe analyser

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CYP2D6*1 (wild type), which is more prevalent in Caucasians, showed that the ratios of intrinsic clearance (Vmax/Km) of *1 to *10 for MDMA O-demethylenation was 123, and for methamphetamine 67, for the p-hydroxylation 157 of the N-demethylation (Ramamoorthy et al., CYP2D6 polymorphism on drug effects are not always reproduced in Asian ones

The FAERS database also revealed 41 reported cases for semaglutide with an ROR of 11.36 (95% CI, 8.33 to 15.49) and a PRR of 11.36 (95% CI, 8.32 to 15.47), suggesting a potential causal relationship between semaglutide and NAION [98]

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