A key strength of this approach is the ability to estimate probabilistic equivalence across multiple dose combinations, rather than relying on pairwise comparisons
At the same time, drugs also have a certain degree of side effects, such as the development of drug resistance, as well as adverse reactions to gastrointestinal symptoms, neurological and psychiatric symptoms, and other systemic symptoms
It's important to acknowledge that these are common, with studies indicating that a significant percentage of users (reports range from 40% up to 85%) experience issues like nausea, vomiting, diarrhea, constipation, bloating, or heartburn, particularly when first starting the medication or increasing the dose
We were especially interested to reveal if there is any association between the incretines like DPP-4 inhibitors and GLP-1RAs and pancreatic cancer, since early on, when these drugs were just released, there were concerns that they may be associated with pancreatitis and with pancreatic cancer, Dankner explained
For example, do alterations of AT truly protect glucose metabolism in PWS
209 , 449.e1449.e7 (2013)