glp-1 gerd GI and Hepatology News GLP‑1 medications do far more

When Wegovy was first approved, it faced prolonged shortages

Yang C, Li D, Teng D, Zhou Y, Zhang L, Zhong Z, et al

Genetic variants that reduce UGT1A1 activity can slow glucuronidation and potentially prolong the negative effects on the endocrine system and liver

During the catabolism of fatty acids with an odd number of carbon atoms and the amino acids valine, isoleucine, methionine, and threonine, the resultant propionyl-CoA is converted to succinyl-CoA for oxidation in the TCA cycle

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And the numbers from clinical trials comparing these two compounds tell a story that is impossible to ignore