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However, these adaptor proteins have different functions as the binding of SH2B or APS to JAK2 enhances its kinase activity whereas LNK binding to JAK2 inhibits its kinase activity (152)

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However, if untreated, a vitamin B12 deficiency can lead to serious symptoms, including nerve damage or pernicious anaemia a condition when your body doesnt have enough B12 to make the red blood cells it needs