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Glutathione depletion can occur through several mechanisms, including insufficient availability of precursor amino acids (particularly cysteine), increased utilization during oxidative stress, low selenium, and impaired recycling from its oxidized form, GSSG

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To address this knowledge gap, here we develop a mathematical model that incorporates the most essential molecular elements for NADPH production, ROS generation, GSH synthesis, and detoxification of ROS by GSH in the outer retina, formed by photoreceptors and the RPE (see Fig