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The trial design included a rigorous oversight process, with approval from relevant institutional review boards and adherence to Good Clinical Practice guidelines

Mechanistic studies using proteasome CP blockers (bortezomib and marizomib) were performed in HeLa and in HeLa cells stably overexpressing IMPDH2 (clone 522-4) to counteract toxicity due to IMPDH2 degradation

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Common excipients such as lactose, sorbitol, or certain colourings may cause digestive upset, particularly in individuals with food intolerances or sensitivities