Therapeutic targeting of proteostasis in cancer Cancer cells are exposed to persistent proteotoxic stress driven by rapid proliferation, genomic instability, hypoxia, metabolic rewiring, and therapeutic pressure
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Diabetes 54 , 13921399 (2005)
J Biol Chem (2005) 280:27508.10.1074/jbc.M410242200 41 Gonzalez-DosalRHoranKARahbekSHIchijoHChenZJMieyalJJet alHSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6
[15] [37] [38] In August 2025, the Food and Drug Administration (FDA) expanded the indication for semaglutide (as Wegovy) to include the treatment of noncirrhotic metabolic-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults
