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Wang's team examined the association of diabetic retinopathy with GLP-1RAs as well as with other glucose-lowering drugs, glucose-lowering drugs excluding insulin, 2 classes of therapeutic alternatives (thiazolidinediones and SGLT2 inhibitors), SGLT2 inhibitors alone, and all other drugs in the database

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Finally, boosting circulating levels of IGF-I by increasing liver production 37 or through daily injections of recombinant IGF-I increases body (and muscle) weight, supporting the premise that circulating IGF-I can enter the local tissue environment and have enhanced anabolic effects