The data suggest an independently regulated nuclear GSH pool and confirm that fluctuations of nuclear GSH are dependent on cell proliferation
Hours after injection: FOXO4-DRI enters circulation and, due to its D-amino acid structure, resists proteolytic degradation
The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)
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A deficiency in thyroid hormones leads to a wide range of clinical manifestations, including fatigue, bradycardia, cold intolerance, weight gain, constipation, depression, and cognitive impairment (Taylor et al., 2024)
