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Vitamin B12 deficiency: Long-term use can lower B12 levels, raising anemia and nerve damage risk

Hansen 2013

And consumer behavior is shifting very rapidly, as more drugs become available in pill form, at a lower price, and from various online sellers without doctor or insurance approvals

Studies have shown that Berberine lowers total cholesterol, LDL cholesterol (the bad one), and triglycerides while increasing HDL cholesterol (the good one)