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The safety of subcutaneous and oral semaglutide will be covered in a separate article in this issue ( Design of The Sustain and Pioneer Programs Both formulations of semaglutide were investigated in comprehensive international clinical development programs

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Synaptogenesis takes time, so the full effect may build over weeks

Users weaning off tirzepatide or managing semaglutide withdrawal should expect dry mouth to gradually improve as tissue levels decrease

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