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Key findings include: GLP3 monotherapy achieved 22.8-24.2% mean weight reduction at 48 weeks in phase 2 obesity trials (8-12 mg doses) Cagrilintide monotherapy produced 10.8% weight loss over 26 weeks in phase 2 studies (2.4 mg dose) CagriSema combination (cagrilintide + semaglutide) achieved 20.4% weight loss at 68 weeks in phase 3 REDEFINE trials Combination approaches consistently outperformed single-agent therapies across multiple dose ranges Studies demonstrated that 100% of participants receiving GLP3 8 mg or higher achieved at least 5% weight loss, with 75-83% achieving 15% or greater weight reduction[9]
This work was funded in part by a grant from Autism Speaks (grant number 7274) to J.V.W
Biochem Biophys Res Com
10.1016/j.cbi.2016.07.026 174 RodriguesM.EzzedineK.HamzaviI.PandyaA
Peer review Peer review information Nature Medicine thanks John Wilding and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
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