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While a vast body of evidence demonstrates a correlation between elevated pro-inflammatory cytokines (e.g., IL-6, TNF-) and depressive severity in IBD patients, the causal impact of pharmacological neutralization of these mediators is still being delineated through rigorous clinical trials (Luo et al., 2025)

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Dysfunction of the UPS is linked to altered sleep timing, reduced circadian rhythm amplitude, and impaired phase resetting, highlighting UPS components as promising targets for correcting circadian disruptions and related disorders