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It is a common form of heart failure in patients with obesity, hypertension, and metabolic syndrome, and it has become a recognized clinical target for incretin-based therapy following the STEP-HFpEF trial (semaglutide in HFpEF with obesity) and the SUMMIT trial (tirzepatide in obesity-related HFpEF)

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This energy is essential for the maintenance of RBCs shape, membrane deformability and regulation of sodium-potassium pump [1, 2]

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