Targeting lactate metabolism for cancer immunotherapy - a matter of precision
However, its close relation with PCOS, obesity, and insulin resistance was not statistically significant, which suggests that its effects could be more related to certain metabolic parameters instead of being globally beneficial in the clinical manifestation of PCOS [133]
Although the reasons for the lack of difference in circulating leptin levels in animals with different degrees of adiposity are unknown, it is possible to speculate that changes in autonomic innervation or hormonal milieu could have affected leptin synthesis and secretion by adipose tissue
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Its potential antioxidant and homeostatic roles remain areas of ongoing interest