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Elevated fumarate has been implicated in metabolic and respiratory diseases, such as airway obstruction and diabetes [83, 84]

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IGF-1 LR3 acts more directly on tissue IGF-1 receptors and has a much longer activity window, but its human safety and efficacy data are essentially absent

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C., Gattinoni, L., Roychoudhuri, R., & Lugli, E