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The dual-pathway approach engages both the GHRH axis (upstream stimulation of GH synthesis and release) and the ghrelin axis (amplification of GH pulse amplitude) simultaneously, which published preclinical data suggests produces greater GH elevation than either compound alone

S., Kim, M

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The future of metabolic therapy likely lies not in single interventions but in carefully orchestrated multi-pathway approaches that address the complex, interconnected systems regulating appetite, metabolism, and body composition