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[PMC free article: PMC3181782] [PubMed: 22033851] 99
This is the mechanistic basis for testing survodutide as a liver drug and not merely a weight-loss drug
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A spokesperson for Eli Lilly told Scientific American that the trial used 7 mg and 14 mg doses of oral semaglutide because they were the only approved doses for type 2 diabetes at the time this trial was designed and executed, adding that the results should be interpreted within the context of the doses studied. If approved by the FDA, orforglipron will be available in six doses1 mg, 3 mg, 6 mg, 12 mg, 24 mg and 36 mgthe spokesperson said
More recently, the open label, non-inferiority trial (REDEFINE-4), comparing CagriSema to tirzepatide showed more disappointment when patients on CagriSema showed up to 23% weight loss compared to Tirzepatide that showed 25.5%
Some studies have shown that increased abdominal visceral fat mass is the best predictor of GH secretion attenuation in humans, and that dietary restriction leading to substantial weight loss restores GH secretion
PMCID: PMC8943615
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