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(Reporting by Chris Prentice in New York and Christy Santhosh in Bengaluru

SURMOUNT-5: The head-to-head trial Published in the New England Journal of Medicine in 2025, SURMOUNT-5 was the first randomised trial to directly compare tirzepatide (Mounjaro) with semaglutide (Wegovy) at equivalent maximum doses in adults with obesity without type 2 diabetes

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In this trial, tirzepatide at all three doses (5 mg, 10 mg, and 15 mg) achieved significantly greater weight loss compared to once weekly semaglutide 1 mg

This methodical approach reflects decades of clinical experience showing that slow titration improves long-term adherence and reduces treatment discontinuation due to side effects

Zhou C, Lin Y