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While complete cartilage regeneration remains beyond current capabilities, peptide support may slow degradation and promote whatever repair potential exists

FDA recommends oligonucleotide therapeutic evaluations, including QTc interval prolongation assessment, immunogenicity risk, hepatic and renal impairment assessments, drug-drug interaction studies (148)

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For example, Medicago and iBio are using Nicotiana benthamiana to produce VLPs using the S protein, and AdaptVac/ExpreS2ion is using insect cell expression system to make VLPs from the S2 protein

Reconstituted solutions are generally advised to be stored at low temperature, shielded from light, and used within a defined experimental window to maintain potency and limit microbial risk, in accordance with local lab practices