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This is noteworthy as these analogues are at least 10-fold less potent then GLP-1-G 2 ( 1 ), meaning that even if at least 10 times more compound is required to get the same activity in vitro, they have a significant longer acting period

ALN-2232: Dedicated RNAi program for obesity & weight management (Phase 1 data expected H2 2026) $4.9-$5.3B projected 2026 revenue, fueling aggressive expansion in metabolic and cardiometabolic pipelines 10+ tissue types & 40+ clinical programs targeted by 2030 ~30% of revenues reinvested into R&D, accelerating next-generation metabolic innovation Reinforces obesity's emergence as a foundational pillar of future medicine ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter Todays popular weight-loss drugs (like Wegovy or Zepbound) are GLP-1 agonists

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The body requires folic acid, vitamin B12, and vitamin B to help break down homocysteine