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A 2-year clinical study in 1991 used low-dose IM DFO (125 mg b.i.d., 5 days/week) in AD patients, which showed a significantly slower (50%) decline in daily living skills, suggesting a disease-slowing effect (Percy et al., 2011)

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Introduction The transcription factor (nuclear factor-erythroid 2 p45-related factor 2, NRF2) is a master regulator of the cellular response to oxidative insults