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The low-selenium condition in combination with three mycotoxins, deoxynivalenol (DON), nivalenol (NIV), and T-2, yielded pro-catabolic changes and hypertrophic phenotype of chondrocytes, as evidenced by the loss of aggrecan and type II collagen (COLII) and the increase in COLX and matrix metalloproteinases (MMPs) expression, respectively 71

The abovementioned product was verified by FDA through postmarketing surveillance and shows no valid Certificate of Product Notification (CPN) as of 30 August 2023, Pursuant to Book II, Article I, Section 1 (a) of the Rules and Regulations Implementing Republic Act No

They can increase oxidative stress and inflammation, disrupt the gut microbiome, and impact the methylation pathway

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Many diets and exercise programs inadvertently lead to muscle loss, which can slow the metabolism and make weight maintenance more difficult