In 2014, the United States Food and Drug Administration (FDA) approved the first GLP-1 drug Saxenda specifically for weight loss
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The key, though, to understanding the sensationalism surrounding peptides comes from a criminal defense attorney quoted in a Mens Health piece about this fad: Many bodybuilders consider themselves on par with lab rats, he said
A separate target trial emulation published in Arthritis & Rheumatology compared 910 initiators of a GLP-1 receptor agonist with 1,004 initiators of a DPP-4 inhibitor among patients with lupus and type 2 diabetes
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A Reuters report (Aug 2025) interviewed multiple US doctors on GLP-1s: insurance coverage has tightened in 2025 as many employers drop it for the expensive GLP-1 drugs, said one physician ( [26] )