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The FDA requires a black-box warning on all GLP-1 medications due to this risk, even though no human cases have been definitively linked to the drugs

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[70,] [71] A randomized trial with 50 human subjects looked at the effect of concurrent vitamin C (five daily doses of 1 g each) and radiotherapy on different tumor types

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In biosimilars specifically, scale matters: the economics favor manufacturers capable of competing on both price and supply reliability simultaneously, because payers and PBMs will not accept single-source biosimilar supply after watching supply disruptions across the generic small-molecule market