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10.1073/pnas.161493498 107 RoyerS.ParD

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Taken together, these in vitro and in vivo data, confirm an essential role for the IGF-I/IGF-IR signaling in promoting both early- and late-stage osteoclastogenesis (Figure 2)

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In a rat OA model, pioglitazone-induced activation of PPAR not only alleviated OA symptoms but also curbed expression of the ferroptosis marker ACSL4