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In SURMOUNT-1, participants with prediabetes showed improvements in glycemic parameters, with approximately 95% of those with prediabetes at baseline achieving normoglycemia at 72 weeks on the 15 mg dose
Metformin is commonly used as first-line therapy unless contraindicated or poorly tolerated, but the addition of glucose-lowering therapies with different mechanisms of action is usually needed to provide adequate glycemic control [1,2,3], with the choice of agent being dependent on multiple factors, such as cost and the presence of comorbidities [1]
Cultures were then diluted to an OD 600 of 0.1
Thus, while the shadow lingers, its far from being a definitive dark spot on the GLP-1 agonist journey
And the population-level data consistently show no signal