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GLP-1 slows digestion and reduces appetite

As you adapt, the side effects will decrease

HDL cholesterol modestly increased across the dose range, while LDL cholesterol showed minimal change a pattern consistent with weight-mediated lipid improvements rather than direct drug effects on LDL pathways

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Reported hypotension was more common with retatrutide than with placebo, and fatigue and dizziness were reported more frequently in the higher-dose groups