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Axford at I24, Diamond Light Source, Oxford, UK for technical support

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Using genetic proxies for l-carnitine minimizes confounding, which is challenging in observational studies

Current diet intake was assessed prior to week 1, and during weeks 3 and 6 of the exercise intervention

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In the chondrocytes of the iron overload model, the levels of GPX4 and SLC7A11 within the antioxidant system were lower, whereas lipid peroxidation levels, indicated by 4-HNE, were higher, and their mitochondria exhibited characteristics similar to ferroptosis (175)