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Although the body produces some of its own glutathione, poor diet, smoking, air pollution, stress, infections and radiation reduce the proportion of glutathione in the body

rather, it converts the carbohydrates into increased liver fat and plasma very-low-density lipoprotein (VLDL) due to hyperinsulinemia

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SILAC delivers high accuracy in cell culture experiments by minimizing downstream processing variability (Harsha et al., 2008), but remains primarily limited to metabolically active, culturable cells, constraining its applicability for direct patient sample analysis