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Furthermore, lactate enhances transforming growth factor (TGF)- signaling in regulatory T cells (Tregs) through non-histone Kla modifications, exemplified by MOESIN Kla at lysine 72, which subsequently attenuates CD8 + T cell functionality (20, 21)

And as a consequence, markers of tissue inflammation also increase as we age because you're sort of removing this anti-inflammatory compound that's released each night

Paintlia et al., 2013a

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