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Additionally, while not age-related, Friedrichs ataxia has also been shown to involve NRF2 regulation of NSC function, as NSC proliferation, self-renewal, and differentiation were all impaired in cortical embryonic NSCs isolated from frataxin-deficient frataxin knock-in/knockout mice (La Rosa et al., 2019)

High-intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin-deficient muscle

In another study, researchers found that combining glutathione with L-citrulline maximizes the production of nitric oxide, which dilates the blood vessels to improve blood flow and oxygen delivery to muscles and tissue [10]

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They also help maintain lipid metabolic crosstalk with mitochondria and the ER via membrane contact sites [189, 190]

Thyroid (2013) 23(1):926