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95% CI 0.590.98

Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW

Neurons are the most abundant cell population in the CNS and are highly susceptible to hypoxia

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Atrial remodeling: (1) Structural remodeling: Multiple factors, including inflammatory responses, paracrine/vasocrine effects of EAT, and elevated chronic hemodynamic stress, can activate atrial fibroblasts, promote their proliferation and differentiation, alter the expression of relevant proteins and cytokines, and ultimately drive the pathogenesis and progression of atrial fibrosis (4045)

The best documented profile of this compound combines two functions: modulation of connective tissue remodeling (stimulation of the synthesis of collagen, elastin and glycosaminoglycans in fibroblasts) and transport of copper ions as a cofactor of matrix enzymes (lysyl oxidase, SOD)