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The addition of GIP receptor activation can restart weight loss that stalled on GLP-1-only therapy

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Tirzepatide (Zepbound) follows a similar four-week interval for dose increases, starting at 2.5 mg and moving up through several steps to a maximum of 15 mg

According to current knowledge, the activity of this enzyme represents the limiting step for fat oxidation [6]

The study reported that once-weekly CagriSema resulted in a significant body weight reduction of 13.7% and a higher percentage of patients achieving an HbA1c level of 6.5% or less, confirming the combination's superior efficacy for both weight loss and glycemic control in this population